Tag Archives: cancer

New Study Indicates Medical Marijuana Could Be A Cure for Cancer

A recent medical marijuana study conducted by two Bay Area scientists has caught the attention of many suffering patients all over the country. For once, medical marijuana isn’t being hailed as a cure for glaucoma or back pain, but as an integral weapon against the most feared disease of all: cancer. 

Dr.Sean McCallister and Dr.Pierre Desperez of the California Pacific Medical Center in San Francisco have found that a compound derived from medical marijuana could stop metastasis in many kinds of aggressive cancer, offering the first legitimate hope for curing cancer in decades.

Despite years of government claims that marijuana has no medicinal properties, multiple studies have shown that tetrahydrocannabinol (THC), the principal psychoactive ingredient of marijuana, is the mortal enemy of the cancer cell. That being said, not everyone that might like to utilize medical marijuana and its potential benefits are interested in smoking or ingesting the plant.

In 2007, Dr. McAllister, a scientist at the Pacific Medical Center in San Francisco who has been studying cannabinoid compounds for 10 years, found that cannabidiol (CBD), a non-psychoactive component of the marijuana plant, is a potent inhibitor of breast cancer cell proliferation, metastasis and tumor growth.

Apparently, cannabidiol kills breast cancer cells and malignant tumors by switching off expression of the ID-1 gene, a protein that appears to play a major role as a cancer cell conductor. The scientists say CBD offers hope of a non-toxic therapy that could treat aggressive forms of cancer without any of the painful side effects of chemotherapy.

The announcement has been hailed by medical marijuana legalization advocates as further proof that the government should stop restricting access to this medically-beneficial plant. Still, the scientists are quick to point out that just smoking a joint won’t cure cancer. ”We used injections in the animal testing and are also testing pills,” said Dr.Desperez.

“But you could never get enough Cannabidiol for it to be effective just from smoking.” In addition, the team has just begun the process of synthesizing the compound in the lab instead of using the  medical marijuana in plant  form in an effort to make it more potent.

The team is hopeful that this development will allow clinical trials to advance as soon as possible.  It is very likely that positive results with human, clinical trials could present the first ray of hope for those suffering from this debilitating disease that has affected many people all over the world. Although development of a synthesized cannabidiol medication would still ultimately benefit pharmaceutical companies,  it may also remove some of the unnecessary controversy that surrounds the use of medical marijuana by young cancer patients.


Scientists Find Cannabis Compound Stops Metastasis In Aggressive Cancers

HuffingtonPost.com

A pair of scientists at California Pacific Medical Center in San Francisco has found that a compound derived from marijuana could stop metastasis in many kinds of aggressive cancer, potentially altering the fatality of the disease forever.

“It took us about 20 years of research to figure this out, but we are very excited,” said Pierre Desprez, one of the scientists behind the discovery, to The Huffington Post. “We want to get started with trials as soon as possible.”

The Daily Beast first reported on the finding, which has already undergone both laboratory and animal testing, and is awaiting permission for clinical trials in humans.

Desprez, a molecular biologist, spent decades studying ID-1, the gene that causes cancer to spread. Meanwhile, fellow researcher Sean McAllister was studying the effects of Cannabidiol, or CBD, a non-toxic, non-psychoactive chemical compound found in the cannabis plant. Finally, the pair collaborated, combining CBD and cells containing high levels of ID-1 in a petri dish.

“What we found was that his Cannabidiol could essentially ‘turn off’ the ID-1,” Desprez told HuffPost. The cells stopped spreading and returned to normal.

“We likely would not have found this on our own,” he added. “That’s why collaboration is so essential to scientific discovery.”

Desprez and McAllister first published a paper about the finding in 2007. Since then, their team has found that CBD works both in the lab and in animals. And now, they’ve found even more good news.

“We started by researching breast cancer,” said Desprez. “But now we’ve found that Cannabidiol works with many kinds of aggressive cancers–brain, prostate–any kind in which these high levels of ID-1 are present.”

Desprez hopes that clinical trials will begin immediately.

“We’ve found no toxicity in the animals we’ve tested, and Cannabidiol is already used in humans for a variety of other ailments,” he said. Indeed, the compound is used to relieve anxiety and nausea, and, since it is non-psychoactive, does not cause the “high” associated with THC.

While marijuana advocates will surely praise the discovery, Desprez explained that it’s not so easy as just lighting up.

“We used injections in the animal testing and are also testing pills,” he said. “But you could never get enough Cannabidiol for it to be effective just from smoking.”

Furthermore, the team has started synthesizing the compound in the lab instead of using the plant in an effort to make it more potent.

“It’s a common practice,” explained Desprez. “But hopefully it will also keep us clear of any obstacles while seeking approval.”

Read more…

 

Study: Non-Psychotropic Plant Cannabinoids Counteract Prostate Cancer Growth

NORML:

The administration of non-psychotropic plant cannabinoids, in particular cannabidiol (CBD), inhibit proliferation and selectively trigger cell suicide of prostate carcinoma, according to preclinical data to be published in the British Journal of Pharmacology. (Read the study abstract online here.)

An international team of investigators from Italy and the United Kingdom assessed the anti-cancer properties of various non-psychoactive synthetic and botanical cannabinoids, including CBD, CBG (cannabigerol), CBN (cannabinol) and THCV (tetrahydrocannabivarin), in vivo and in vitro (in culture).

Researchers reported, “The … data presented here allow us to suggest that non-THC cannabinoids, and CBD in particular, retard proliferation and cause apoptosis (programmed cell death) of prostate carcinoma growth via a combination of cannabinoid receptor-independent cellular and molecular mechanisms. … We suggest that non-THC cannabinoids … might provide the basis for the development of novel therapeutic strategies for the treatment of prostate carcinoma.”

Prostate cancer is the second most common cancer in American men. It is the second leading cause of cancer death in American males, trailing only behind lung cancer.

Read more.

Top News of the Week

Support comes from an unlikely source this week as a notably conservative politician’s daughter publicly endorses marijuana legalization, while New York takes great steps in legalizing medical marijuana. Rhode Island meanwhile lessens the punishment for possessing marijuana; possessing an ounce or less will become a civil violation with a $150, like a ticket. Read on for the full stories.

Meghan McCain Speaks Out in Support of Legalization

The Arizona conservative Senator’s daughter went on a cross-country roadtrip with liberal comedian Michael Ian Black. They toured cultural sites, discussed gay marriage and gun rights, and wrote it all down for us to read in America, You Sexy Bitch: A Love Letter to Freedom.

On the Tonight Show with Jay Leno, she discusses why she supports the legalization of marijuana:


California Hospital Denies transplant for Legal MMJ User

Patient Toni Trujillo has been on the Cedars-Sinai Medical Center’s transplant list waiting for a kidney for six years…until now. Trujillo has been using medical marijuana legally for two years to stimulate her appetite and increase and maintain protein levels while on dialysis, yet she was removed from the list for “substance abuse.”

This isn’t the first time this has happened, either.  Last year the hospital removed a man with inoperable liver cancer from their transplant list for the same reason – legally smoking marijuana. Without the transplant, doctors expect him to die within 90 days.

From DrugFree.org:
Sally Stewart, a spokesperson for the hospital, said marijuana users can be exposed to a type of mold that can cause deadly disease among patients whose immune systems are compromised. They also are at risk of a fatal lung infection after transplantation, she told the newspaper. “We do not make a moral or ethical judgment about people who are smoking medical marijuana. Our concern is strictly for the health and safety of our patients,” she said.

NY General Assembly Approves Medical Marijuana Bill; RI Decriminalizes

The same day that Rhode Island Governor Chafee signed a bill to decriminalize the possession of small amounts of marijuana, the New York State Assembly approved a bill to allow qualified patients to possess medical marijuana. The vote passed 90-50, setting a positive note for the Senate vote. Similar legislation have previously been stopped twice in the Senate, but supporters are optimistic for AB7347’s passing. Tell your New York Senator to support the bill here.